Professor Sharpless developed stereoselective oxidation reactions and discovered amino hydroxylation, dihydroxylation, and the Sharpless asymmetric epoxidation. Click chemistry was introduced by Sharpless inThis is a synthetic concept initially proposed in 1998 and further refined in 2001. Its core principle is to achieve rapid and reliable chemical synthesis of diverse molecules through the ligation of small units. The Sharpless group developed a new generation of "click chemistry" reactions based on sulfur-fluoride exchange (SuFEx) sulfonyl fluoride chemistry. This reaction holds immense application prospects in fields such as materials synthesis and drug development. In recognition of his pioneering achievements in click chemistry, Professor Sharpless...2022YearObtainedObtainThe second Nobel Prize.